Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

INTRODUCTION: The cytoprotective PTEN‐induced kinase 1 (PINK1)‐parkin RBR E3 ubiquitin protein ligase (PRKN) pathway selectively labels damaged mitochondria with phosphorylated ubiquitin (pS65‐Ub) for their autophagic removal (mitophagy). Because dysfunctions of mitochondria and degradation pathways...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Alzheimers Dement
Main Authors: Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Featured Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048674/
https://ncbi.nlm.nih.gov/pubmed/33090691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12198
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados