Structure-Activity Correlations for β-Phenethylamines at Human Trace Amine Receptor 1

Por Lewin, Anita H., Navarro, Hernán A., Mascarella, S. Wayne
Publicado em 2008

1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists

Por Carroll, F. Ivy, Cueva, Juan Pablo, Thomas, James B., Mascarella, S. Wayne, Runyon, Scott P., Navarro, Hernán A.
Publicado em 2010

N-Substituted cis-4a-(3-Hydroxyphenyl)-8a-methyloctahydroisoquinolines Are Opioid Receptor Pure Antagonists

Por Carroll, F. Ivy, Chaudhari, Sachin, Thomas, James B., Mascarella, S. Wayne, Gigstad, Kenneth M., Deschamps, Jeffrey, Navarro, Hernán A.
Publicado em 2005

Synthesis and Nicotinic Acetylcholine Receptor In Vitro and In Vivo Pharmacological Properties of 2'-Fluoro-3'-(substituted phenyl)deschloroepibatidine Analogues of 2'-Fluoro-3'-(4...

Por Ondachi, Pauline, Castro, Ana, Luetje, Charles W., Damaj, M. Imad, Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2012

Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam

Por Gichinga, Moses G., Olson, Jeremy P., Butala, Elizabeth, Navarro, Hernán A., Gilmour, Brian P., Mascarella, S. Wayne, Carroll, F. Ivy
Publicado em 2011

Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Smoking Cessation

Por Carroll, F. Ivy, Blough, Bruce E., Mascarella, S. Wayne, Navarro, Hernán A., Eaton, J. Brek, Lukas, Ronald J., Damaj, M. Imad
Publicado em 2010

Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2β-substituted Tropanes

Por Carroll, F. Ivy, Blough, Bruce E., Mascarella, S. Wayne, Navarro, Hernán A., Eaton, J. Brek, Lukas, Ronald J., Damaj, M. Imad
Publicado em 2010

Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor

Por Chang, Steven D., Mascarella, S. Wayne, Spangler, Skylar M., Gurevich, Vsevolod V., Navarro, Hernan A., Carroll, F. Ivy, Bruchas, Michael R.
Publicado no Mol Pharmacol (2015)

Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthes...

Por Runyon, Scott P., Brieaddy, Lawrence E., Mascarella, S. Wayne, Thomas, James B., Navarro, Hernán A., Howard, James L., Pollard, Gerald T., Carroll, F. Ivy
Publicado em 2010

4β-Methyl-5-(3-hydroxyphenyl)morphan Opioid Agonist and Partial Agonist Derived from a 4β-Methyl-5-(3-hydroxyphenyl)morphan Pure Antagonist

Por Carroll, F. Ivy, Gichinga, Moses G., Williams, John D., Vardy, Eyal, Roth, Bryan L., Mascarella, S. Wayne, Thomas, James B., Navarro, Hernán A.
Publicado em 2013

Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs

Por Ondachi, Pauline W., Ye, Zhuo, Castro, Ana H., Luetje, Charles W., Damaj, M. Imad, Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Publicado no Bioorg Med Chem (2015)

Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2′-Fluoro-3′-(substituted pyridinyl)-7-deschloroepibatidine Analogues

Por Ondachi, Pauline W., Castro, Ana H., Bartkowiak, Jakub M., Luetje, Charles W., Damaj, M. Imad, Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2014

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres

Por Kormos, Chad M., Gichinga, Moses G., Runyon, Scott P., Thomas, James B., Mascarella, S. Wayne, Decker, Ann M., Navarro, Hernán A., Carroll, F. Ivy
Publicado no Bioorg Med Chem (2016)

Synthesis of 2-(Substituted phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of...

Por Carroll, F. Ivy, Muresan, Ana Z., Blough, Bruce E., Navarro, Hernán A., Mascarella, S. Wayne, Eaton, J. Brek, Huang, Xiaodong, Damaj, M. Imad, Lukas, Ronald J.
Publicado em 2011

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoqu...

Por Kormos, Chad M., Gichinga, Moses G., Maitra, Rangan, Runyon, Scott P., Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2014

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents

Por Carroll, F. Ivy, Gichinga, Moses G., Kormos, Chad M., Maitra, Rangan, Runyon, Scott P., Thomas, James B., Mascarella, S. Wayne, Decker, Ann M., Navarro, Hernán A.
Publicado no Bioorg Med Chem (2015)

Discovery of N-{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide Analogues as Selective Kappa Opioid Receptor Antagonists

Por Kormos, Chad M., Jin, Chunyang, Cueva, Juan Pablo, Runyon, Scott P, Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Navarro, Hernán A., Gilmour, Brian P., Carroll, F. Ivy
Publicado em 2013

Synthesis and Characterization of In Vitro and In Vivo Profiles of Hydroxybupropion Analogues: Aids to Smoking Cessation

Por Lukas, Ronald J., Muresan, Ana Z., Damaj, M. Imad, Blough, Bruce E., Huang, Xiaodong, Navarro, Hernán A., Mascarella, S. Wayne, Eaton, J. Brek, Marxer-Miller, Syndia K., Carroll, F. Ivy
Publicado em 2010

Effect of the 3- and 4-Methyl Groups on the Opioid Receptor Properties of N-Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines

Por Kormos, Chad M., Cueva, Juan Pablo, Gichinga, Moses G., Runyon, Scott P., Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Gilmour, Brian P., Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2014

Structure of the human kappa opioid receptor in complex with JDTic

Por Wu, Huixian, Wacker, Daniel, Katritch, Vsevolod, Mileni, Mauro, Han, Gye Won, Vardy, Eyal, Liu, Wei, Thompson, Aaron A., Huang, Xi-Ping, Carroll, F. Ivy, Mascarella, S. Wayne, Westkaemper, Richard B., Mosier, Philip D., Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Publicado em 2012