Synthesis and Nicotinic Acetylcholine Receptor In Vitro and In Vivo Pharmacological Properties of 2'-Fluoro-3'-(substituted phenyl)deschloroepibatidine Analogues of 2'-Fluoro-3'-(4-nitrophenyl)deschloroepibatidine (4-Nitro-PFEB or RTI-7527-102)

Herein, we report the synthesis and nicotinic acetylcholine receptor (nAChR) in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidines 5b–g, analogues of 3'-(4-nitrophenyl) compound 5a. All compounds had high affinity for the α4β2-nAChR...

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Detalhes bibliográficos
Main Authors: Ondachi, Pauline, Castro, Ana, Luetje, Charles W., Damaj, M. Imad, Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431023/
https://ncbi.nlm.nih.gov/pubmed/22742586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300575y
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