Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2′-Fluoro-3′-(substituted pyridinyl)-7-deschloroepibatidine Analogues

[Image: see text] 2′-Fluoro-3-(substituted pyridine)epibatidine analogues 7a–e and 8a–e were synthesized, and their in vitro and in vivo nAChR properties were determined. 2′-Fluoro-3′-(4″-pyridinyl)deschloroepibatidine (7a) and 2′-fluoro-3′-(3″-pyridinyl)deschloroepibatidine (8a) were synthesized as...

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Detalhes bibliográficos
Main Authors: Ondachi, Pauline W., Castro, Ana H., Bartkowiak, Jakub M., Luetje, Charles W., Damaj, M. Imad, Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983394/
https://ncbi.nlm.nih.gov/pubmed/24428686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401602p
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