Synthesis of 2-(Substituted phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine

Toward development of smoking cessation aids superior to bupropion (2), we describe synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues 5a–5h and their effects on inhibition of dopamine, norepinephrine, and serotonin uptake, nicotinic acetylcholine receptor (nAChR) function, acut...

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Detalhes bibliográficos
Main Authors: Carroll, F. Ivy, Muresan, Ana Z., Blough, Bruce E., Navarro, Hernán A., Mascarella, S. Wayne, Eaton, J. Brek, Huang, Xiaodong, Damaj, M. Imad, Lukas, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048909/
https://ncbi.nlm.nih.gov/pubmed/21319801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1014555
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