Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs

Over the last several years we have synthesized and studied the in vitro and in vivo nAChR pharmacological properties of epibatidine (4) analogs. In this study we report the synthesis, nAChR in vitro and in vivo pharmacological properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs (5...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Ondachi, Pauline W., Ye, Zhuo, Castro, Ana H., Luetje, Charles W., Damaj, M. Imad, Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554999/
https://ncbi.nlm.nih.gov/pubmed/26233800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.021
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