Synthesis, Nicotinic Acetylcholine Receptor Binding, and Pharmacological Properties of 3’- (Substituted phenyl) Deschloroepibatidine Analogs

A series of 3’-(substituted phenyl)deschloroepibatidine analogs (5a–j) were synthesized. The α4β2* and α7 nicotinic acetylcholine receptor (nAChR) binding properties and functional activity in the tail-flick, hot-plate, locomotor, and body temperature tests in mice of 5a–j were compared to those of...

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Hauptverfasser: Ivy Carroll, F., Yokota, Yasuno, Ma, Wei, Lee, Jeffrey R., Brieaddy, Lawrence E., Burgess, Jason P., Navarro, Hernán A., Damaj, M.I., Martin, Billy R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374917/
https://ncbi.nlm.nih.gov/pubmed/17964169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.027
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