Structure of the human kappa opioid receptor in complex with JDTic

Opioid receptors (ORs) mediate the actions of endogenous and exogenous opioids for many essential physiological processes including regulation of pain, respiratory drive, mood, and, in the case of κ-opioid receptors (KOR), dysphoria and psychotomimesis. Here we report the crystal structure of the hu...

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Main Authors: Wu, Huixian, Wacker, Daniel, Katritch, Vsevolod, Mileni, Mauro, Han, Gye Won, Vardy, Eyal, Liu, Wei, Thompson, Aaron A., Huang, Xi-Ping, Carroll, F. Ivy, Mascarella, S. Wayne, Westkaemper, Richard B., Mosier, Philip D., Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356457/
https://ncbi.nlm.nih.gov/pubmed/22437504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10939
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