Structure of the human kappa opioid receptor in complex with JDTic

Opioid receptors (ORs) mediate the actions of endogenous and exogenous opioids for many essential physiological processes including regulation of pain, respiratory drive, mood, and, in the case of κ-opioid receptors (KOR), dysphoria and psychotomimesis. Here we report the crystal structure of the hu...

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Bibliographic Details
Main Authors:	Wu, Huixian, Wacker, Daniel, Katritch, Vsevolod, Mileni, Mauro, Han, Gye Won, Vardy, Eyal, Liu, Wei, Thompson, Aaron A., Huang, Xi-Ping, Carroll, F. Ivy, Mascarella, S. Wayne, Westkaemper, Richard B., Mosier, Philip D., Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3356457/ https://ncbi.nlm.nih.gov/pubmed/22437504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10939
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Structure of the human kappa opioid receptor in complex with JDTic

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