Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists

The crystal structures of opioid receptors provide a novel platform for inquiry into opioid receptor function. The molecular determinants for activation of the κ-opioid receptor (KOR) were studied using a combination of agonist docking, functional assays, and site-directed mutagenesis. Eighteen posi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Vardy, Eyal, Mosier, Philip D., Frankowski, Kevin J., Wu, Huixian, Katritch, Vsevolod, Westkaemper, Richard B., Aubé, Jeffrey, Stevens, Raymond C., Roth, Bryan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843062/
https://ncbi.nlm.nih.gov/pubmed/24121503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515668
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi