Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists

The crystal structures of opioid receptors provide a novel platform for inquiry into opioid receptor function. The molecular determinants for activation of the κ-opioid receptor (KOR) were studied using a combination of agonist docking, functional assays, and site-directed mutagenesis. Eighteen posi...

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Autores principales: Vardy, Eyal, Mosier, Philip D., Frankowski, Kevin J., Wu, Huixian, Katritch, Vsevolod, Westkaemper, Richard B., Aubé, Jeffrey, Stevens, Raymond C., Roth, Bryan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843062/
https://ncbi.nlm.nih.gov/pubmed/24121503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515668
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