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1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists

[Image: see text] This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl)piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxyphenyl)piperazine, both of which...

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Библиографические подробности
Главные авторы: Carroll, F. Ivy, Cueva, Juan Pablo, Thomas, James B., Mascarella, S. Wayne, Runyon, Scott P., Navarro, Hernán A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2010
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992360/
https://ncbi.nlm.nih.gov/pubmed/21116435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100126b
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