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Discovery of N-{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide Analogues as Selective Kappa Opioid Receptor Antagonists

There is continuing interest in the discovery and development of new κ opioid receptor antagonists. We recently reported that N-substituted 3-methyl-4-(3-hydroxyphenyl)piperazines were a new class of opioid receptor antagonists. In this study we report the syntheses of two piperazine JDTic-like anal...

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Bibliografske podrobnosti
Main Authors: Kormos, Chad M., Jin, Chunyang, Cueva, Juan Pablo, Runyon, Scott P, Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Navarro, Hernán A., Gilmour, Brian P., Carroll, F. Ivy
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701944/
https://ncbi.nlm.nih.gov/pubmed/23651437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400275h
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