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Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)()

In previous structure–activity relationship (SAR) studies, (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic, 3) was identified as the first potent and selective κ-opioid receptor antagonist f...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Cueva, Juan Pablo, Cai, Tingwei Bill, Mascarella, S. Wayne, Thomas, James B., Navarro, Hernán A., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584631/
https://ncbi.nlm.nih.gov/pubmed/19954245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900756t
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