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Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3, 4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats

RATIONALE: The kappa opioid receptor (KOR) antagonist, JDTic, was reported to prevent stress-induced reinstatement of cocaine-maintained responding and to have antidepressant-like effects. OBJECTIVES: Our objectives were to determine whether analogs of JDTic retained KOR antagonist activity and whet...

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Detalhes bibliográficos
Main Authors: Beardsley, Patrick M., Pollard, Gerald T., Howard, James L., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872796/
https://ncbi.nlm.nih.gov/pubmed/20372878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-1846-3
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