Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats

Por Schmoutz, Christopher D, Zhang, Yanan, Runyon, Scott P, Goeders, Nicholas E
Publicado em 2012

Identifying Structural Features on 1,1-Diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones Critical For Neuropeptide S Antagonist Activity

Por Zhang, Yanan, Gilmour, Brian P., Navarro, Hernán A., Runyon, Scott P.
Publicado no Bioorg Med Chem Lett (2008)

Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) i...

Por Bonano, Julie S., Runyon, Scott P., Hassler, Carla, Glennon, Richard A., Negus, S. Stevens
Publicado no Eur J Pharmacol (2014)

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists

Por Perrey, David A., Gilmour, Brian P., Runyon, Scott P., Thomas, Brian F., Zhang, Yanan
Publicado em 2011

Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT(2A) Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis...

Por Runyon, Scott P., Mosier, Philip D., Roth, Bryan L., Glennon, Richard A., Westkaemper, Richard B.
Publicado em 2008

1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists

Por Carroll, F. Ivy, Cueva, Juan Pablo, Thomas, James B., Mascarella, S. Wayne, Runyon, Scott P., Navarro, Hernán A.
Publicado em 2010

Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthes...

Por Runyon, Scott P., Brieaddy, Lawrence E., Mascarella, S. Wayne, Thomas, James B., Navarro, Hernán A., Howard, James L., Pollard, Gerald T., Carroll, F. Ivy
Publicado em 2010

Identification of Neuropeptide S Antagonists: Structure–Activity Relationship Studies, X-ray Crystallography, and in Vivo Evaluation

Por Hassler, Carla, Zhang, Yanan, Gilmour, Brian, Graf, Tyler, Fennell, Timothy, Snyder, Rodney, Deschamps, Jeffrey R., Reinscheid, Rainer K., Garau, Celia, Runyon, Scott P.
Publicado em 2014

The Importance of the 6- and 7-Positions of Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor

Por Perrey, David A., Decker, Ann M., Li, Jun-Xu, Gilmour, Brian P., Thomas, Brian F., Harris, Danni L., Runyon, Scott P., Zhang, Yanan
Publicado no Bioorg Med Chem (2015)

Discovery of a Novel Small Molecule Agonist Scaffold for the APJ Receptor

Por Narayanan, Sanju, Maitra, Rangan, Deschamps, Jeffery R., Bortoff, Katherine, Thomas, James B., Zhang, Yanyan, Warner, Keith, Vasukuttan, Vineetha, Decker, Ann, Runyon, Scott P.
Publicado no Bioorg Med Chem (2016)

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres

Por Kormos, Chad M., Gichinga, Moses G., Runyon, Scott P., Thomas, James B., Mascarella, S. Wayne, Decker, Ann M., Navarro, Hernán A., Carroll, F. Ivy
Publicado no Bioorg Med Chem (2016)

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoqu...

Por Kormos, Chad M., Gichinga, Moses G., Maitra, Rangan, Runyon, Scott P., Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2014

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the Neurotensin receptor type 2

Por Thomas, James B., Giddings, Angela M., Olepu, Srinivas, Wiethe, Robert W., Warner, Keith R., Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P., Gilmour, Brian P
Publicado no Bioorg Med Chem Lett (2015)

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents

Por Carroll, F. Ivy, Gichinga, Moses G., Kormos, Chad M., Maitra, Rangan, Runyon, Scott P., Thomas, James B., Mascarella, S. Wayne, Decker, Ann M., Navarro, Hernán A.
Publicado no Bioorg Med Chem (2015)

Discovery of N-{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide Analogues as Selective Kappa Opioid Receptor Antagonists

Por Kormos, Chad M., Jin, Chunyang, Cueva, Juan Pablo, Runyon, Scott P, Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Navarro, Hernán A., Gilmour, Brian P., Carroll, F. Ivy
Publicado em 2013

Effect of 1-Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin-1 Receptor

Por Perrey, David A., German, Nadezhda A., Decker, Ann M., Thorn, David, Li, Jun-Xu, Gilmour, Brian P., Thomas, Brian F., Harris, Danni L., Runyon, Scott P., Zhang, Yanan
Publicado no ACS Chem Neurosci (2015)

Effect of the 3- and 4-Methyl Groups on the Opioid Receptor Properties of N-Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines

Por Kormos, Chad M., Cueva, Juan Pablo, Gichinga, Moses G., Runyon, Scott P., Thomas, James B., Brieaddy, Lawrence E., Mascarella, S. Wayne, Gilmour, Brian P., Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2014

Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the N...

Por Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Publicado em 2014

Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compo...

Por Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Publicado no J Med Chem (2014)

Enhanced Bioactivity of Silybin B Methylation Products

Por Sy-Cordero, Arlene A., Graf, Tyler N., Runyon, Scott P., Wani, Mansukh C., Kroll, David J., Agarwal, Rajesh, Brantley, Scott J., Paine, Mary F., Polyak, Stephen J., Oberlies, Nicholas H.
Publicado em 2012