Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

[Image: see text] Compounds acting via the neurotensin receptor type 2 (NTS2) are known to be active in animal models of acute and chronic pain. To identify novel NTS2 selective analgesics, we searched for NTS2 selective nonpeptide compounds using a FLIPR assay and identified the title compound (NTR...

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Autores principales: Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161155/
https://ncbi.nlm.nih.gov/pubmed/25157640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500857r
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