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Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists
As a part of our program to develop OX1-CB1 bivalent ligands, we required a better understanding of the basic structure-activity relationships (SARs) of orexin antagonists. A series of SB-334867 analogues were synthesized and evaluated in calcium mobilization assays. SAR results suggest that the 2-m...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3085582/ https://ncbi.nlm.nih.gov/pubmed/21478014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.048 |
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