SB-334867-A: the first selective orexin-1 receptor antagonist

The pharmacology of various peptide and non-peptide ligands was studied in Chinese hamster ovary (CHO) cells stably expressing human orexin-1 (OX(1)) or orexin-2 (OX(2)) receptors by measuring intracellular calcium ([Ca(2+)](i)) using Fluo-3AM. Orexin-A and orexin-B increased [Ca(2+)](i) in CHO-OX(1...

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Hlavní autoři: Smart, D, Sabido-David, C, Brough, S J, Jewitt, F, Johns, A, Porter, R A, Jerman, J C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
Témata:
Special Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572677/
https://ncbi.nlm.nih.gov/pubmed/11250867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703953
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