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The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors
The pharmacology of the orexin-like peptides, hypocretin-1 and hypocretin-2, was studied in Chinese hamster ovary (CHO) cells stably expressing orexin-1 (OX(1)) or orexin-2 (OX(2)) receptors by measuring intracellular calcium ([Ca(2+)](i)) using Fluo-3AM. Orexin-A and orexin-B increased [Ca(2+)](i)...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571990/ https://ncbi.nlm.nih.gov/pubmed/10742282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703257 |
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