Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity

Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties. One of them, 1-(3,4-dichlorophenyl)-2-[2-imino-3-(4-methylbenzyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl]ethan-1-ol (Yan 7874), is commercially...

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Bibliographic Details
Published in:PLoS One
Main Authors: Turku, Ainoleena, Rinne, Maiju K., Boije af Gennäs, Gustav, Xhaard, Henri, Lindholm, Dan, Kukkonen, Jyrki P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456073/
https://ncbi.nlm.nih.gov/pubmed/28575023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178526
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