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Effect of 1-Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin-1 Receptor
Selective blockade of the Orexin-1 receptor has been suggested as a potential approach to drug addiction therapy because of its role in modulating the brain's reward system. We have recently reported a series of tetrahydroisoquinoline-based OX(1) selective antagonists. Aimed at elucidating SAR...
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| Publié dans: | ACS Chem Neurosci |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4400266/ https://ncbi.nlm.nih.gov/pubmed/25643283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500330v |
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