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Synthesis and Evaluation of Orexin-1 Receptor Antagonists with Improved Solubility and CNS Permeability
Orexins are hypothalamic neuropeptides playing important roles in many functions including the motivation of addictive behaviors. Blockade of the orexin-1 receptor has been suggested as a potential strategy for the treatment of drug addiction. We have previously reported OX(1) receptor antagonists b...
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| Publicado no: | ACS Chem Neurosci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6002953/ https://ncbi.nlm.nih.gov/pubmed/29129052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00402 |
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