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Synthesis and Evaluation of Orexin-1 Receptor Antagonists with Improved Solubility and CNS Permeability

Orexins are hypothalamic neuropeptides playing important roles in many functions including the motivation of addictive behaviors. Blockade of the orexin-1 receptor has been suggested as a potential strategy for the treatment of drug addiction. We have previously reported OX(1) receptor antagonists b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Neurosci
Prif Awduron: Perrey, David A., Decker, Ann M., Zhang, Yanan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002953/
https://ncbi.nlm.nih.gov/pubmed/29129052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00402
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