The Importance of the 6- and 7-Positions of Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor

Selective antagonism of the orexin 1 (OX(1)) receptor has been proposed as a potential mechanism for treatment of drug addiction. We have previously reported studies on the structure-activity relationships of tetrahydroisoquinoline-based antagonists. In this report, we elucidated the respective role...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Perrey, David A., Decker, Ann M., Li, Jun-Xu, Gilmour, Brian P., Thomas, Brian F., Harris, Danni L., Runyon, Scott P., Zhang, Yanan
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554834/
https://ncbi.nlm.nih.gov/pubmed/26216017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.013
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