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Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor
Increasing evidence implicates the orexin 1 (OX(1)) receptor in reward processes, suggesting OX(1) antagonism could be therapeutic in drug addiction. In a program to develop an OX(1) selective antagonist, we designed and synthesized a series of substituted tetrahydroisoquinolines and determined thei...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849818/ https://ncbi.nlm.nih.gov/pubmed/23941044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400720h |
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