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Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists

As a part of our program to develop OX1-CB1 bivalent ligands, we required a better understanding of the basic structure-activity relationships (SARs) of orexin antagonists. A series of SB-334867 analogues were synthesized and evaluated in calcium mobilization assays. SAR results suggest that the 2-m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Perrey, David A., Gilmour, Brian P., Runyon, Scott P., Thomas, Brian F., Zhang, Yanan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085582/
https://ncbi.nlm.nih.gov/pubmed/21478014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.048
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