Identification of Neuropeptide S Antagonists: Structure–Activity Relationship Studies, X-ray Crystallography, and in Vivo Evaluation

[Image: see text] Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-ones were synthe...

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Detalhes bibliográficos
Main Authors: Hassler, Carla, Zhang, Yanan, Gilmour, Brian, Graf, Tyler, Fennell, Timothy, Snyder, Rodney, Deschamps, Jeffrey R., Reinscheid, Rainer K., Garau, Celia, Runyon, Scott P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140596/
https://ncbi.nlm.nih.gov/pubmed/24964000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500113c
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