Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists

In order to gain additional information concerning the active conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine (1) class of opioid receptor antagonists, procedures were developed for the synthesis of structurally rigid N-substituted-6-(3-hydroxy-phenyl)3-azabicyclo[...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Runyon, Scott P., Kormos, Chad M., Gichinga, Moses G., Mascarella, S. Wayne, Navarro, Hernán A., Deschamps, Jeffrey R., Imler, Gregory H., Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586075/
https://ncbi.nlm.nih.gov/pubmed/27462910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b01366
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