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4β-Methyl-5-(3-hydroxyphenyl)morphan Opioid Agonist and Partial Agonist Derived from a 4β-Methyl-5-(3-hydroxyphenyl)morphan Pure Antagonist

In previous studies we reported that addition of 7α-acylamino groups to N-phenylpropyl-4β-methyl-5-(3-hydroxyphenyl)morphan (4) led to compounds that were pure opioid receptor antagonists. In contrast to these findings we report in this study that addition of a 7α-amino (5a), 7α-alkylamino (5b–e), o...

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Detalhes bibliográficos
Main Authors: Carroll, F. Ivy, Gichinga, Moses G., Williams, John D., Vardy, Eyal, Roth, Bryan L., Mascarella, S. Wayne, Thomas, James B., Navarro, Hernán A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893112/
https://ncbi.nlm.nih.gov/pubmed/24144404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401250s
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