N-Substituted cis-4a-(3-Hydroxyphenyl)-8a-methyloctahydroisoquinolines Are Opioid Receptor Pure Antagonists

N-Substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines (6a–g) were designed and synthesized as conformationally constrained analogues of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine (4) class of opioid receptor pure antagonists. The methyloctahydroisoquinolines 6a–g can exist...

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Detalhes bibliográficos
Main Authors: Carroll, F. Ivy, Chaudhari, Sachin, Thomas, James B., Mascarella, S. Wayne, Gigstad, Kenneth M., Deschamps, Jeffrey, Navarro, Hernán A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585695/
https://ncbi.nlm.nih.gov/pubmed/16366600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm058261c
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