Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam

[Image: see text] In an effort to discover potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists, 15 tetrahydropyrimidinone analogues of 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-urea (fenobam) were synthesized. These compounds were evaluated fo...

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Main Authors: Gichinga, Moses G., Olson, Jeremy P., Butala, Elizabeth, Navarro, Hernán A., Gilmour, Brian P., Mascarella, S. Wayne, Carroll, F. Ivy
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328804/
https://ncbi.nlm.nih.gov/pubmed/22523618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200162f
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