The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine

Metabotropic glutamate receptor subtype 5 (mGlu5) has been demonstrated to play a role in the modulation of numerous nociceptive modalities. When administered via peripheral, intrathecal, or systemic routes, mGlu5 antagonists have analgesic properties in a variety of preclinical pain models. Despite...

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Detalles Bibliográficos
Main Authors: Montana, Michael C., Cavallone, Laura F., Stubbert, Kristi K., Stefanescu, Andrei D., Kharasch, Evan D., Gereau, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Neuropharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729799/
https://ncbi.nlm.nih.gov/pubmed/19515968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.154138
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