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Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam
[Image: see text] In an effort to discover potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists, 15 tetrahydropyrimidinone analogues of 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-urea (fenobam) were synthesized. These compounds were evaluated fo...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American
Chemical Society
2011
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328804/ https://ncbi.nlm.nih.gov/pubmed/22523618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200162f |
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