Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for R...

Bằng Kazzouli, Saïd El, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E.
Được phát hành 2008

Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC

Bằng Petersen, Mark E., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Keck, Gary E.
Xuất bản năm Tetrahedron Lett (2016)

Biochemical characterization of hyperactive β2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains

Bằng Sosa, Maria Soledad, Lewin, Nancy E., Choi, Sung-Hee, Blumberg, Peter M., Kazanietz, Marcelo G.
Được phát hành 2009

Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency

Bằng Zhao, Xiguang, Kedei, Noemi, Michalowski, Alexandra, Lewin, Nancy E., Keck, Gary E., Blumberg, Peter M.
Xuất bản năm Chembiochem (2018)

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

Bằng Ohashi, Nami, Nomura, Wataru, Kato, Mai, Narumi, Tetsuo, Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Được phát hành 2009

The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses

Bằng Keck, Gary E., Li, Wei, Kraft, Matthew B., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Được phát hành 2009

Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding

Bằng Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Lewin, Nancy E., Itotani, Kyoko, Blumberg, Peter M., Tamamura, Hirokazu
Được phát hành 2010

Membrane anchoring of diacylglycerol-lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

Bằng Raifman, Or, Kolusheva, Sofiya, Comin, Maria J., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Được phát hành 2009

Role of the C(8) gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

Bằng Keck, Gary E., Poudel, Yam B., Rudra, Arnab, Stephens, Jeffrey C., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Được phát hành 2012

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-Like Biology

Bằng Ketcham, John M., Volchkov, Ivan, Chen, Te-Yu, Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Krische, Michael J.
Xuất bản năm J Am Chem Soc (2016)

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation

Bằng Das, Joydip, Kedei, Noemi, Kelsey, Jessica S., You, Youngki, Pany, Satyabrata, Mitchell, Gary A., Lewin, Nancy E., Blumberg, Peter M.
Xuất bản năm Biochemistry (2018)

Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

Bằng Ann, Jihyae, Yoon, Suyoung, Baek, Jisoo, Kim, Da Hye, Lewin, Nancy E., Hill, Colin S., Blumberg, Peter M., Lee, Jeewoo
Xuất bản năm Eur J Med Chem (2014)

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

Bằng Choi, Sung Hee, Czifra, Gabriella, Kedei, Noemi, Lewin, Nancy E., Lazar, Jozsef, Pu, Yongmei, Marquez, Victor E., Blumberg, Peter M.
Được phát hành 2008

Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the l...

Bằng Kang, Ji-Hye, Peach, Megan L., Pu, Yongmei, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.
Được phát hành 2005

Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13...

Bằng Andrews, Ian P., Ketcham, John M., Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Krische, Michael J.
Được phát hành 2014

Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

Bằng Kraft, Matthew B., Poudel, Yam B., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Blumberg, Peter M., Keck, Gary E.
Được phát hành 2014

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

Bằng Pu, Yongmei, Kang, Ji-Hye, Sigano, Dina M., Peach, Megan L., Lewin, Nancy E., Marquez, Victor E., Blumberg, Peter M.
Xuất bản năm J Med Chem (2014)

Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface

Bằng Philosof-Mazor, Liron, Volinsky, Roman, Comin, Maria J., Lewin, Nancy E., Kedei, Noemi, Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Được phát hành 2008

Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands

Bằng Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K., Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Xuất bản năm Bioconjug Chem (2017)

Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)

Bằng Rahman, Ghazi M., Shanker, Sreejesh, Lewin, Nancy E., Kedei, Noemi, Hill, Colin S., Prasad, B. V. Venkataram, Blumberg, Peter M., Das, Joydip
Xuất bản năm Biochem J (2013)