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Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency

Important strides are being made in understanding the effects of structural features of bryostatin 1, a candidate therapeutic agent for cancer and dementia, in conferring its potency for protein kinase C and on the unique spectrum of biological responses which it induces. A critical pharmacophoric e...

詳細記述

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書誌詳細
出版年:Chembiochem
主要な著者: Zhao, Xiguang, Kedei, Noemi, Michalowski, Alexandra, Lewin, Nancy E., Keck, Gary E., Blumberg, Peter M.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032040/
https://ncbi.nlm.nih.gov/pubmed/29517836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700677
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