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Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency
Important strides are being made in understanding the effects of structural features of bryostatin 1, a candidate therapeutic agent for cancer and dementia, in conferring its potency for protein kinase C and on the unique spectrum of biological responses which it induces. A critical pharmacophoric e...
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| Опубликовано в: : | Chembiochem |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7032040/ https://ncbi.nlm.nih.gov/pubmed/29517836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700677 |
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