Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for R...

od Kazzouli, Saïd El, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E.
Izdano 2008

Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC

od Petersen, Mark E., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Keck, Gary E.
Izdano u Tetrahedron Lett (2016)

Biochemical characterization of hyperactive β2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains

od Sosa, Maria Soledad, Lewin, Nancy E., Choi, Sung-Hee, Blumberg, Peter M., Kazanietz, Marcelo G.
Izdano 2009

Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency

od Zhao, Xiguang, Kedei, Noemi, Michalowski, Alexandra, Lewin, Nancy E., Keck, Gary E., Blumberg, Peter M.
Izdano u Chembiochem (2018)

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

od Ohashi, Nami, Nomura, Wataru, Kato, Mai, Narumi, Tetsuo, Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Izdano 2009

The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses

od Keck, Gary E., Li, Wei, Kraft, Matthew B., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Izdano 2009

Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding

od Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Lewin, Nancy E., Itotani, Kyoko, Blumberg, Peter M., Tamamura, Hirokazu
Izdano 2010

Synthetic Caged DAG-lactones for Photochemically Controlled Activation of Protein Kinase C

od Nomura, Wataru, Narumi, Tetsuo, Ohashi, Nami, Serizawa, Yuki, Lewin, Nancy E., Blumberg, Peter M., Furuta, Toshiaki, Tamamura, Hirokazu
Izdano u Chembiochem (2011)

Membrane anchoring of diacylglycerol-lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

od Raifman, Or, Kolusheva, Sofiya, Comin, Maria J., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Izdano 2009

Role of the C(8) gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

od Keck, Gary E., Poudel, Yam B., Rudra, Arnab, Stephens, Jeffrey C., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Izdano 2012

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-Like Biology

od Ketcham, John M., Volchkov, Ivan, Chen, Te-Yu, Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Krische, Michael J.
Izdano u J Am Chem Soc (2016)

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation

od Das, Joydip, Kedei, Noemi, Kelsey, Jessica S., You, Youngki, Pany, Satyabrata, Mitchell, Gary A., Lewin, Nancy E., Blumberg, Peter M.
Izdano u Biochemistry (2018)

Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

od Ann, Jihyae, Yoon, Suyoung, Baek, Jisoo, Kim, Da Hye, Lewin, Nancy E., Hill, Colin S., Blumberg, Peter M., Lee, Jeewoo
Izdano u Eur J Med Chem (2014)

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

od Choi, Sung Hee, Czifra, Gabriella, Kedei, Noemi, Lewin, Nancy E., Lazar, Jozsef, Pu, Yongmei, Marquez, Victor E., Blumberg, Peter M.
Izdano 2008

Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the l...

od Kang, Ji-Hye, Peach, Megan L., Pu, Yongmei, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.
Izdano 2005

Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13...

od Andrews, Ian P., Ketcham, John M., Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Krische, Michael J.
Izdano 2014

Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

od Kraft, Matthew B., Poudel, Yam B., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Blumberg, Peter M., Keck, Gary E.
Izdano 2014

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

od Pu, Yongmei, Kang, Ji-Hye, Sigano, Dina M., Peach, Megan L., Lewin, Nancy E., Marquez, Victor E., Blumberg, Peter M.
Izdano u J Med Chem (2014)

Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface

od Philosof-Mazor, Liron, Volinsky, Roman, Comin, Maria J., Lewin, Nancy E., Kedei, Noemi, Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Izdano 2008

Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands

od Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K., Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Izdano u Bioconjug Chem (2017)