Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for R...

Por Kazzouli, Saïd El, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E.
Publicado em 2008

Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC

Por Petersen, Mark E., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Keck, Gary E.
Publicado no Tetrahedron Lett (2016)

Biochemical characterization of hyperactive β2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains

Por Sosa, Maria Soledad, Lewin, Nancy E., Choi, Sung-Hee, Blumberg, Peter M., Kazanietz, Marcelo G.
Publicado em 2009

Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency

Por Zhao, Xiguang, Kedei, Noemi, Michalowski, Alexandra, Lewin, Nancy E., Keck, Gary E., Blumberg, Peter M.
Publicado no Chembiochem (2018)

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

Por Ohashi, Nami, Nomura, Wataru, Kato, Mai, Narumi, Tetsuo, Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Publicado em 2009

The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses

Por Keck, Gary E., Li, Wei, Kraft, Matthew B., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Publicado em 2009

Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding

Por Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Lewin, Nancy E., Itotani, Kyoko, Blumberg, Peter M., Tamamura, Hirokazu
Publicado em 2010

Membrane anchoring of diacylglycerol-lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

Por Raifman, Or, Kolusheva, Sofiya, Comin, Maria J., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Publicado em 2009

Role of the C(8) gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

Por Keck, Gary E., Poudel, Yam B., Rudra, Arnab, Stephens, Jeffrey C., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Publicado em 2012

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-Like Biology

Por Ketcham, John M., Volchkov, Ivan, Chen, Te-Yu, Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Krische, Michael J.
Publicado no J Am Chem Soc (2016)

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation

Por Das, Joydip, Kedei, Noemi, Kelsey, Jessica S., You, Youngki, Pany, Satyabrata, Mitchell, Gary A., Lewin, Nancy E., Blumberg, Peter M.
Publicado no Biochemistry (2018)

Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

Por Ann, Jihyae, Yoon, Suyoung, Baek, Jisoo, Kim, Da Hye, Lewin, Nancy E., Hill, Colin S., Blumberg, Peter M., Lee, Jeewoo
Publicado no Eur J Med Chem (2014)

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

Por Choi, Sung Hee, Czifra, Gabriella, Kedei, Noemi, Lewin, Nancy E., Lazar, Jozsef, Pu, Yongmei, Marquez, Victor E., Blumberg, Peter M.
Publicado em 2008

Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the l...

Por Kang, Ji-Hye, Peach, Megan L., Pu, Yongmei, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.
Publicado em 2005

Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13...

Por Andrews, Ian P., Ketcham, John M., Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Krische, Michael J.
Publicado em 2014

Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

Por Kraft, Matthew B., Poudel, Yam B., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Blumberg, Peter M., Keck, Gary E.
Publicado em 2014

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

Por Pu, Yongmei, Kang, Ji-Hye, Sigano, Dina M., Peach, Megan L., Lewin, Nancy E., Marquez, Victor E., Blumberg, Peter M.
Publicado no J Med Chem (2014)

Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface

Por Philosof-Mazor, Liron, Volinsky, Roman, Comin, Maria J., Lewin, Nancy E., Kedei, Noemi, Blumberg, Peter M., Marquez, Victor E., Jelinek, Raz
Publicado em 2008

Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands

Por Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K., Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Publicado no Bioconjug Chem (2017)

Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)

Por Rahman, Ghazi M., Shanker, Sreejesh, Lewin, Nancy E., Kedei, Noemi, Hill, Colin S., Prasad, B. V. Venkataram, Blumberg, Peter M., Das, Joydip
Publicado no Biochem J (2013)