Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties

[Image: see text] The seco-B-ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 30 total steps with three bonds formed via hydrogen-mediated C–C coupling. This synthetic route features a palladium-catalyzed alkoxycarbonylation of a C(2)-symmetric diol...

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Bibliographic Details
Main Authors: Andrews, Ian P., Ketcham, John M., Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Krische, Michael J.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183601/
https://ncbi.nlm.nih.gov/pubmed/25207655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507825s
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