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Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-Like Biology

The synthesis and biological evaluation of chromane-containing bryostatin analogues WN-2 to WN-7 and the previously reported salicylate-based analogue WN-8 are described. Analogues WN-2 to WN-7 are prepared through convergent assembly of the chromane-containing Fragment B-I with the “binding domain”...

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Dades bibliogràfiques
Publicat a:J Am Chem Soc
Autors principals: Ketcham, John M., Volchkov, Ivan, Chen, Te-Yu, Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Krische, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094189/
https://ncbi.nlm.nih.gov/pubmed/27676096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08695
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