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Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-Like Biology
The synthesis and biological evaluation of chromane-containing bryostatin analogues WN-2 to WN-7 and the previously reported salicylate-based analogue WN-8 are described. Analogues WN-2 to WN-7 are prepared through convergent assembly of the chromane-containing Fragment B-I with the “binding domain”...
Gorde:
| Argitaratua izan da: | J Am Chem Soc |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5094189/ https://ncbi.nlm.nih.gov/pubmed/27676096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08695 |
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