Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters

[Image: see text] A close structural analogue of bryostatin 1, which differs from bryostatin 1 only by the absence of the C(30) carbomethoxy group (on the C(13) enoate of the B-ring), has been prepared by total synthesis. Biological assays reveal a crucial role for substitution in the bryostatin 1 A...

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Detalhes bibliográficos
Main Authors: Keck, Gary E., Poudel, Yam B., Welch, Dennie S., Kraft, Matthew B., Truong, Anh P., Stephens, Jeffrey C., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647801/
https://ncbi.nlm.nih.gov/pubmed/19113896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8027253
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