Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action

Bryostatin 1, like the phorbol esters, binds to and activates protein kinase C (PKC) but paradoxically antagonizes many but not all phorbol ester responses. Previously, we have compared patterns of biological response to bryostatin 1, phorbol ester, and the bryostatin 1 derivative Merle 23 in two hu...

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Hauptverfasser: Kedei, N., Telek, A., Michalowski, A.M., Kraft, M.B., Li, W., Poudel, Y.B., Rudra, A., Petersen, M.E., Keck, G.E., Blumberg, P.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553297/
https://ncbi.nlm.nih.gov/pubmed/23146662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.10.028
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