Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing

Por Tamamura, Hirokazu, Tsutsumi, Hiroshi, Nomura, Wataru, Fujii, Nobutaka
Publicado em 2008

HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent PKA signaling in cultured rat microglia

Por Xu, Changshui, Liu, Jianuo, Chen, Lina, Liang, Shangdong, Fujii, Nobutaka, Tamamura, Hirokazu, Xiong, Huangui
Publicado em 2011

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

Por Ohashi, Nami, Nomura, Wataru, Kato, Mai, Narumi, Tetsuo, Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Publicado em 2009

Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds

Por Yoshimura, Kazuhisa, Harada, Shigeyoshi, Shibata, Junji, Hatada, Makiko, Yamada, Yuko, Ochiai, Chihiro, Tamamura, Hirokazu, Matsushita, Shuzo
Publicado em 2010

Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding

Por Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Lewin, Nancy E., Itotani, Kyoko, Blumberg, Peter M., Tamamura, Hirokazu
Publicado em 2010

Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs

Por Nakata, Hirotomo, Steinberg, Seth M., Koh, Yasuhiro, Maeda, Kenji, Takaoka, Yoshikazu, Tamamura, Hirokazu, Fujii, Nobutaka, Mitsuya, Hiroaki
Publicado em 2008

T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure

Por Arakaki, Rieko, Tamamura, Hirokazu, Premanathan, Mariappan, Kanbara, Kenji, Ramanan, Sivasundaram, Mochizuki, Katsura, Baba, Masanori, Fujii, Nobutaka, Nakashima, Hideki
Publicado em 1999

Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions

Por Nameki, Daisuke, Kodama, Eiichi, Ikeuchi, Mieko, Mabuchi, Naoto, Otaka, Akira, Tamamura, Hirokazu, Ohno, Mutsuhito, Fujii, Nobutaka, Matsuoka, Masao
Publicado em 2005

Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gα(i) activation.

Por Berchiche, Yamina A., Chow, Ken Y., Lagane, Bernard, Leduc, Martin, Percherancier, Yann, Fujii, Nobutaka, Tamamura, Hirokazu, Bachelerie, Françoise, Heveker, Nikolaus
Publicado em 2011

CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells

Por Kabashima, Kenji, Shiraishi, Noriko, Sugita, Kazunari, Mori, Tomoko, Onoue, Ayako, Kobayashi, Miwa, Sakabe, Jun-ichi, Yoshiki, Ryutaro, Tamamura, Hirokazu, Fujii, Nobutaka, Inaba, Kayo, Tokura, Yoshiki
Publicado em 2007

A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

Por Murakami, Tsutomu, Nakajima, Toshihiro, Koyanagi, Yoshio, Tachibana, Kazunobu, Fujii, Nobutaka, Tamamura, Hirokazu, Yoshida, Nobuaki, Waki, Michinori, Matsumoto, Akiyoshi, Yoshie, Osamu, Kishimoto, Tadamitsu, Yamamoto, Naoki, Nagasawa, Takashi
Publicado em 1997

Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies

Por Suzuki, Shintaro, Maddali, Kasthuraiah, Hashimoto, Chie, Urano, Emiko, Ohashi, Nami, Tanaka, Tomohiro, Ozaki, Taro, Arai, Hiroshi, Tsutsumi, Hiroshi, Narumi, Tetsuo, Nomura, Wataru, Yamamoto, Naoki, Pommier, Yves, Komano, Jun A., Tamamura, Hirokazu
Publicado no Bioorg Med Chem (2010)

Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection

Por Murakami, Tsutomu, Zhang, Tian-Yuan, Koyanagi, Yoshio, Tanaka, Yuetsu, Kim, Jin, Suzuki, Yoichi, Minoguchi, Shigeru, Tamamura, Hirokazu, Waki, Michinori, Matsumoto, Akiyoshi, Fujii, Nobutaka, Shida, Hisatoshi, Hoxie, James A., Peiper, Stephen C., Yamamoto, Naoki
Publicado em 1999

Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection

Por Murakami, Tsutomu, Zhang, Tian-Yuan, Koyanagi, Yoshio, Tanaka, Yuetsu, Kim, Jin, Suzuki, Yoichi, Minoguchi, Shigeru, Tamamura, Hirokazu, Waki, Michinori, Matsumoto, Akiyoshi, Fujii, Nobutaka, Shida, Hisatoshi, Hoxie, James A., Peiper, Stephen C., Yamamoto, Naoki
Publicado em 2002

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

Por Yamada, Mitsuhiro, Kubo, Hiroshi, Kobayashi, Seiichi, Ishizawa, Kota, He, Mei, Suzuki, Takaya, Fujino, Naoya, Kunishima, Hiroyuki, Hatta, Masamitsu, Nishimaki, Katsushi, Aoyagi, Tetsuji, Tokuda, Kouichi, Kitagawa, Miho, Yano, Hisakazu, Tamamura, Hirokazu, Fujii, Nobutaka, Kaku, Mitsuo
Publicado em 2011

Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products

Por Suzuki, Shintaro, Urano, Emiko, Hashimoto, Chie, Tsutsumi, Hiroshi, Nakahara, Toru, Tanaka, Tomohiro, Nakanishi, Yuta, Maddali, Kasthuraiah, Han, Yan, Hamatake, Makiko, Miyauchi, Kosuke, Pommier, Yves, Beutler, John A., Sugiura, Wataru, Fuji, Hideyoshi, Hoshino, Tyuji, Itotani, Kyoko, Nomura, Wataru, Narumi, Tetsuo, Yamamoto, Naoki, Komano, Jun A., Tamamura, Hirokazu
Publicado no J Med Chem (2010)