T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure

T22, an analog of polyphemusin II (18 amino acid residues), was found to block T-tropic human immunodeficiency virus type 1 (HIV-1) entry into target cells as a CXCR4 inhibitor. We synthesized T134, a small analog (14 amino acid residues) of T22 with reduced positive charges. T134 exhibited highly p...

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Detaylı Bibliyografya
Asıl Yazarlar: Arakaki, Rieko, Tamamura, Hirokazu, Premanathan, Mariappan, Kanbara, Kenji, Ramanan, Sivasundaram, Mochizuki, Katsura, Baba, Masanori, Fujii, Nobutaka, Nakashima, Hideki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 1999
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC104006/
https://ncbi.nlm.nih.gov/pubmed/9882387
Etiketler: Etiketle
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