T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure

T22, an analog of polyphemusin II (18 amino acid residues), was found to block T-tropic human immunodeficiency virus type 1 (HIV-1) entry into target cells as a CXCR4 inhibitor. We synthesized T134, a small analog (14 amino acid residues) of T22 with reduced positive charges. T134 exhibited highly p...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Arakaki, Rieko, Tamamura, Hirokazu, Premanathan, Mariappan, Kanbara, Kenji, Ramanan, Sivasundaram, Mochizuki, Katsura, Baba, Masanori, Fujii, Nobutaka, Nakashima, Hideki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104006/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9882387/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.2.1719-1723.1999
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