HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent PKA signaling in cultured rat microglia

Microglia are critical cells in mediating the pathophysiology of neurodegenerative disorders such as HIV-associated neurocognitive disorders. We hypothesize that HIV-1 glycoprotein 120 (gp120) activates microglia by enhancing outward K(+) currents, resulting in microglia secretion of neurotoxins and...

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Main Authors: Xu, Changshui, Liu, Jianuo, Chen, Lina, Liang, Shangdong, Fujii, Nobutaka, Tamamura, Hirokazu, Xiong, Huangui
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077451/
https://ncbi.nlm.nih.gov/pubmed/21438014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21171
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