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Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding

Protein kinase C (PKC) is a critical cell signaling pathway involved in many disorders such as cancer and Alzheimer-type dementia. To date, evaluation of PKC ligand binding affinity has been performed by competitive studies against radiolabelled probes that are problematic for high-throughput screen...

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Main Authors: Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Lewin, Nancy E., Itotani, Kyoko, Blumberg, Peter M., Tamamura, Hirokazu
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076627/
https://ncbi.nlm.nih.gov/pubmed/21175182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100414a
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