Charge density influences C1 domain ligand affinity and membrane interactions

The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analog the phorbol esters, has emerged as a promising therapeutic target for cancer and other indications. Potential target selectivity is markedly enhance...

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Detalhes bibliográficos
Main Authors: Kelsey, Jessica S., Geczy, Tamas, Lewin, Nancy E., Kedei, Noemi, Hill, Colin S., Selezneva, Julia S., Valle, Christopher J., Woo, Wonhee, Gorshkova, Inna, Blumberg, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112953/
https://ncbi.nlm.nih.gov/pubmed/24777910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201400041
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