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Molecular Basis for Failure of “Atypical” C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester

C1 domains, the recognition motif of the second messenger diacylglycerol and of the phorbol esters, are classified as typical (ligand-responsive) or atypical (not ligand-responsive). The C1 domain of Vav1, a guanine nucleotide exchange factor, plays a critical role in regulation of Vav activity thro...

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Main Authors: Geczy, Tamas, Peach, Megan L., El Kazzouli, Saïd, Sigano, Dina M., Kang, Ji-Hye, Valle, Christopher J., Selezneva, Julia, Woo, Wonhee, Kedei, Noemi, Lewin, Nancy E., Garfield, Susan H., Lim, Langston, Mannan, Poonam, Marquez, Victor E., Blumberg, Peter M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340006/
https://ncbi.nlm.nih.gov/pubmed/22351766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.320010
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