Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity

The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and related proteins. RasGRP2 is exceptional in that its C1 domain has very weak binding affinity (K(d) = 2890 ± 240 nm for [(3)H]phorbol 12,1...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Czikora, Agnes, Lundberg, Daniel J., Abramovitz, Adelle, Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Zhou, Xiaoling, Merritt, Raymond C., Craft, Elizabeth A., Braun, Derek C., Blumberg, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900263/
https://ncbi.nlm.nih.gov/pubmed/27022025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725333
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