Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity

The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and related proteins. RasGRP2 is exceptional in that its C1 domain has very weak binding affinity (K(d) = 2890 ± 240 nm for [(3)H]phorbol 12,1...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Czikora, Agnes, Lundberg, Daniel J., Abramovitz, Adelle, Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Zhou, Xiaoling, Merritt, Raymond C., Craft, Elizabeth A., Braun, Derek C., Blumberg, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900263/
https://ncbi.nlm.nih.gov/pubmed/27022025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725333
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares