Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity

The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and related proteins. RasGRP2 is exceptional in that its C1 domain has very weak binding affinity (K(d) = 2890 ± 240 nm for [(3)H]phorbol 12,1...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Czikora, Agnes, Lundberg, Daniel J., Abramovitz, Adelle, Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Zhou, Xiaoling, Merritt, Raymond C., Craft, Elizabeth A., Braun, Derek C., Blumberg, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900263/
https://ncbi.nlm.nih.gov/pubmed/27022025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725333
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