Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity

The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and related proteins. RasGRP2 is exceptional in that its C1 domain has very weak binding affinity (K(d) = 2890 ± 240 nm for [(3)H]phorbol 12,1...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Czikora, Agnes, Lundberg, Daniel J., Abramovitz, Adelle, Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Zhou, Xiaoling, Merritt, Raymond C., Craft, Elizabeth A., Braun, Derek C., Blumberg, Peter M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2016
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900263/
https://ncbi.nlm.nih.gov/pubmed/27022025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725333
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